There’s another 50th anniversary in the life of President John F. Kennedy that’s important to remember today.
Just a few weeks before his death, on October 11, 1963, President Kennedy received the final report of the President’s Commission on the Status of Women. A direct line runs between the work of this commission and the establishment of the National Organization for Women.
In 1961, President Kennedy issued an executive order charging the commission “with the responsibility for developing recommendations for overcoming discrimination in government and private employment on the basis of sex…”
The preamble to the executive order begins with the following statement:
Prejudices and outmoded customs act as barriers to the full realization of women’s basic rights, which should be respected and fostered as part of our Nation’s commitment to human dignity, freedom, and democracy.
President Kennedy appointed Eleanor Roosevelt to chair the Commission, which she did until her death in 1962.
(You can listen to a conversation between Eleanor Roosevelt and President Kennedy about the Commission here).
As Dr. Ellen Fitzpatrick, Professor of History at University of New Hampshire, said in a video produced for a conference marking the 50th anniversary of the Commission that was held by the John F. Kennedy Presidential Library and Museum and the Radcliffe Institute for Advanced Study at Harvard University,
In appointing a presidential commission on the status of women, Kennedy was calling attention at the very most senior level of our government to the problem that there was structurally within our society enormous inequality and discrimination against women that needed to be redressed, and that was a very significant thing to have done.
The Commission’s final report, entitled American Women: Report of the President’s Commission, was presented to President Kennedy on October 11, 1963, which would have been Eleanor Roosevelt’s 79th birthday. Its central recommendation was that women should have equal political, civil and economic rights and responsibilities. That was a radical notion in 1963 — fifty years later it is one of the central principles of our efforts for equality.
Another important outgrowth of President Kennedy’s commission was that it sparked the creation of commissions on the status of women in all fifty states. By 1967, every state had one.
At a meeting in 1966 of state commissions in Washington, D.C., delegates discussed a resolution demanding that the Equal Employment Opportunity Commission (EEOC) carry out its legal mandate to end sex discrimination in employment.
These advocates for women were told — not for the first time, nor the last — that they wouldn’t be allowed to take action. But they were determined.
Writer Betty Friedan and Dr. Pauli Murray, a Yale law professor and member of President Kennedy’s Commission on the Status of Women, were delegates to the conference and along with other attendees met in Friedan’s hotel room to discuss strategies for taking meaningful action. As this history of the National Organization for Women describes, the groundwork was set in motion then and there for a new civil rights organization that would become NOW.
The work of the commission and other progressive women’s groups helped to draw attention to gender-based discrimination in the United States, which eventually led to a renewed push to pass the Equal Rights Amendment to the U.S. Constitution, first proposed by Alice Paul after women won the vote in 1920.
Today — with growing income and wealth disparities that particularly affect women in communities of color; with more and more states blocking women’s access to abortion, birth control and other reproductive health services; and with radical Tea Party extremists doing all they can to turn back the clock on women’s economic security and even our ability to be safe from domestic violence and sexual assault — a constitutional guarantee of full equality for all women is more important than ever.
While President Kennedy did not support the ERA as it was discussed in the early 1960s, (nor did the commission, in fact), I believe he might have changed his views and come to agree with his brother, Senator Edward Kennedy, who was a champion of women’s rights and the ERA for over thirty years, and was instrumental in getting the measure passed by the Senate in 1972.
The cause of equality for women is an important part of John F. Kennedy’s legacy, and I hope that women everywhere join me today in thinking about how President Kennedy would want us to continue the work he began fifty years ago.
Originally published on Terry O’Neill’s Huffington Post blog on 11/21/2013
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Sermorelin, a synthetic growth hormone releasing
peptide that mimics the natural GHRH (growth hormone-releasing hormone), and the combination of CJC-1295 with ipamorelin have both gained popularity among those seeking to boost endogenous growth
hormone production for anti-aging, athletic performance, or body composition goals.
While sermorelin is often prescribed as a single agent, many users opt for the dual peptide strategy of CJC-1295 and
ipamorelin because each contributes unique advantages that complement one another.
Benefits of Combining Ipamorelin with CJC 1295
When used together, CJC-1295 and ipamorelin create a synergistic effect on growth hormone secretion. CJC-1295 is a long-acting analog of
GHRH; it stimulates the pituitary gland to release growth hormone
over an extended period (typically 24–48 hours) due
to its slow clearance from the body. Ipamorelin, on the other hand,
is a selective ghrelin receptor agonist that triggers the pituitary to secrete
growth hormone in short, sharp bursts. The combination therefore delivers both sustained baseline levels of growth
hormone cycle before and after dianabol periodic spikes that
can enhance muscle anabolism, fat loss, tissue repair, and
overall energy metabolism.
In addition to hormonal benefits, pairing these peptides improves tolerability.
Ipamorelin is known for its minimal impact on cortisol or prolactin release, reducing the risk of side
effects such as water retention, sleep disturbances, or mood changes that can accompany other growth hormone-releasing
mimetics. The combined regimen also offers a more natural rhythm of secretion, resembling
the circadian pattern seen in healthy adults, which may translate to better sleep quality and metabolic health.
Understanding Ipamorelin and CJC 1295
CJC-1295 is a synthetic decapeptide that closely resembles endogenous GHRH but has been modified to resist enzymatic breakdown. Its half-life ranges
from 4 to 8 hours when used alone, yet when conjugated with a fatty acid chain (as in the long-acting formulation),
it can persist for up to 24–48 hours. This prolonged activity allows
patients to receive a single daily injection that maintains elevated growth hormone levels throughout
the day and night.
Ipamorelin is a hexapeptide that selectively
activates the ghrelin receptor, stimulating the
pituitary gland to release growth hormone without significant stimulation of other hormones such as cortisol
or prolactin. Its rapid onset (within 30–60 minutes)
leads to brief but potent peaks in growth hormone concentration. The short duration also reduces the likelihood of excessive fluid
retention and allows for a more physiological pattern of secretion.
The combination of these two peptides therefore offers both a
sustained release of GHRH activity via CJC-1295 and a
complementary, rapid stimulation by ipamorelin. Together they achieve higher total daily exposure to growth
hormone than either agent alone while minimizing side effects
that could arise from overstimulation or hormonal imbalance.
What Is Ipamorelin?
Ipamorelin is a synthetic peptide comprising six amino acids (Gly-Glu-Phe-Lys-Pro-Trp).
It was originally developed in the early 2000s as part of a research program to create selective ghrelin receptor agonists.
Unlike other growth hormone-releasing peptides such as GHRP-2 or GHRP-6, ipamorelin has a unique binding profile that confers high specificity for
the growth hormone secretagogue receptor (GHSR). This
specificity translates into a strong stimulation of growth hormone
release with minimal off-target effects.
Clinically, ipamorelin is used in combination with CJC-1295 to produce a dual-peptide protocol.
The peptide is typically administered via subcutaneous injection once or twice daily,
depending on the desired hormonal profile and patient tolerance.
Common dosage ranges for ipamorelin alone are 200–400 micrograms per
injection, but when combined with CJC-1295 users often start at lower doses (100–200 micrograms) to
mitigate any potential side effects while still achieving a synergistic
response.
Because ipamorelin is a short peptide, it is relatively inexpensive to
synthesize and can be produced in high purity. Its pharmacokinetics are well characterized: after
injection it reaches peak plasma concentration within 30 minutes, peaks in growth hormone levels within an hour, and then declines
over the next few hours. This transient spike is ideal for
mimicking the natural pulse of growth hormone secretion that occurs during sleep
or intense exercise.
In summary, ipamorelin offers a safe, targeted way to elevate growth hormone levels without
disturbing other endocrine axes. When paired with the long-acting CJC-1295, users can achieve both sustained and pulsatile stimulation of growth hormone production, potentially enhancing muscle hypertrophy, fat loss, recovery, and overall vitality while keeping side
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Possession of anabolic steroids for the purpose of trafficking is
subject to a most penalty of five years imprisonment and/or a fine of four hundred penalty units (DPCSA s73(1)(c)).
If you might have been charged in relation to the
use, possession or trafficking of anabolic steroids or another
drug of dependence, please contact an experienced drug expenses lawyer.
Dribbin & Brown Legal Attorneys can assist you in understanding the costs and your choices
and guide you through the legal course of.
According to section 171(2) of the Crimes Act 1900, any individual discovered
supplying anabolic steroids to another individual for use could additionally be guilty of an offence.
If discovered guilty, the individual may be
required to pay a nice of up to 500 penalty items, and may withstand 5
years imprisonment.
It is legal to possess steroids for private use,
but it’s illegal to import, manufacture, provide, or sell them with no valid prescription from a healthcare professional.
These rules are in place to protect the well being and
security of the public and to take care of the integrity of professional
sports activities. Anabolic steroids are artificial drugs designed to imitate the effects of testosterone.
Medical professionals generally prescribe them for particular well being circumstances (for instance, hypogonadism, where the physique isn’t making sufficient sex hormones).
For responsible use, healthcare suppliers can also recommend post-cycle therapy (PCT) after steroid cessation.
These supplements are not controlled substances, comprise
no banned ingredients, and can be found over-the-counter or online
with no prescription. Though steroids aren’t all exactly the identical, they
work in much the same method, whether it’s the
natural type (testosterone) or artificial model. We use the time period
steroids right here as a end result of that’s what
lots of people are conversant in. Some preliminary information regarding the time course of HPGA recovery
after AAS use have lately been printed (176).
When gonadal function was normal earlier than an AAS cycle, there was a 90% likelihood of having
normal testosterone levels 3 months after cessation and a 100 percent chance on the finish of follow-up (1 yr after the beginning of the cycle).
At the group stage, mean testosterone ranges returned to baseline three months after cessation.
Shopping For from an unverified source can also end in shopping for low-quality or unsafe products that may harm your well being.
Furthermore, buying steroids on-line and not using
a prescription can end result in legal consequences, together with fines and imprisonment.
Selective Androgen Receptor Modulators (SARMS) are sometimes seen as a safer different to anabolic steroids as they’ll stimulate the androgen receptor in the same means as pure testosterone.
As per the Therapeutic Goods Administration (TGA), SARMS are categorised as a Schedule 4
drug beneath the Poisons Normal. This signifies that they are prescription-only medicines and it’s unlawful to
purchase or possess them without a legitimate prescription from a licensed medical practitioner.
Dr. Wansink also pointed out that this increased development was doubtless because of
the improve in creatine phosphate ranges within the blood, which can help increase testosterone ranges.
Selective Androgen Receptor Modulators, commonly often identified as SARMS, are also subjected to legal regulations in Queensland, Australia.
Over‑the‑counter products such as authorized SARMs (Selective Androgen Receptor Modulators) are nonetheless murky legally, so research fastidiously and seek the advice of a well being professional.
Utilizing anabolic steroids can result in addiction, as a end result of people rely on the medication for confidence and shallowness.
There is an exception for anabolic steroids in products packaged for ovulation control
or in quantities which might lawfully be prescribed.
The sale or supply of steroids can also be prohibited, with
the offence carrying a most penalty of 4 years imprisonment and/or a $19,
500 fantastic (100 penalty units). It is an offence to own,
use or administer steroids to another individual,
with a most penalty of 2 years imprisonment and/or a $9,
750 fine (50 penalty items x present worth of $195).
There can also be a separate offence for trafficking or making an attempt to
traffick anabolic and androgenic steroidal agents, with a maximum penalty of 15 years imprisonment applicable.
Most different AAS usually are not a substrate for aromatase or are converted at decrease charges, though the latter group can nonetheless
yield a considerable quantity of estrogen if administered in high doses.
The produced estrogen subsequently exerts its results by binding to estrogen receptors α and
β, thereby diversifying the organic results of
the mother or father compound. Estrogen production is particularly relevant in light of the event of gynecomastia and the
unfavorable endocrine suggestions exerted on the hypothalamic–pituitary–gonadal axis (HPGA).
We describe its role herein in additional detail
within the subsections on Gynecomastia and Testosterone Deficiency.
DHT could be subsequently inactivated to 3α-androstanediol (3α-diol) by 3α-hydroxysteroid-dehydrogenase (3αHSD).
In two double-blind randomized-controlled trials, hemodialysis
sufferers received one hundred mg oxymetholone day by day for 24 weeks and none of those patients
developed indicators of liver harm (108, 109). The HAARLEM examine also found no (sub)acute
clinical signs of liver damage despite 67% of topics reporting the use
of oral AAS (39). The lack of proof however, some AAS customers resort to ancillary medication –
corresponding to minoxidil and the 5α-reductase inhibitors finasteride and dutasteride – to counteract potential hair loss.
While the effectiveness of 5α-reductase inhibitors is evident in medical apply
(75), their use within the context of high dosages of
testosterone and/or different AAS is unproven and doubtful at finest.
Any DHT-lowering effect may be simply compensated for by the
increased androgenic motion of supraphysiological circulating testosterone
levels. One notable exception is nandrolone, which is converted into
dihydronandrolone (DHN) by 5α-reductase.
Anabolic steroids are legally allowed for medical purposes but require a prescription. Medical Doctors prescribe these medicine for situations like low testosterone and
sure forms of cancer. Beneath medical supervision, anabolic steroids can successfully treat particular well being points.
In Victoria, the Medicine, Poisons and Controlled Substances Act 1981 (Vic) (the
DPCSA) establishes multiple offences referring to the possession,
use, manufacture and trafficking of drugs of dependence.
As ‘anabolic and androgenic steroidal agents’ are
thought of a drug of dependence underneath the DPSCA, the unauthorised
use of anabolic steroids is unlawful. Yes, a doctor can prescribe anabolic steroids to treat various medical circumstances.
These embody hormone-related issues corresponding to delayed puberty in males and low testosterone ranges in individuals with testicular
illness or pituitary failure.
There are plenty of different methods to coach and
prepare for a boxing match that don’t involve unlawful medicine.
And if you’re caught with any amount of the drug in your possession, you presumably can count on to face some serious penalties.
However, that could change sooner or later as the nation has been recognized to revise its legal guidelines from time to time.
Analyzing steroids like this one may be very harsh on liver
features and might trigger long-term harm.
France additionally treats anabolic steroids harshly, with legal guidelines that criminalize both possession and distribution. In France, athletes
caught utilizing performance-enhancing medication face
not only legal penalties but also bans from their respective sports.
The latter is a synthetic form of testosterone that
medical doctors could prescribe to treat sure hormonal or muscle-wasting situations.
Individuals typically misuse anabolic steroids to increase muscle mass and boost athletic efficiency.
Nonetheless, these drugs might have dangerous unwanted effects and are unlawful
without a prescription.
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